Statistical and Computational Pharmacogenomics

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Statistical and Computational Pharmacogenomics 368 pages Chapman & Hall/CRC; 1 edition (August 8, 2008) ISBN 1584888288 PDF 3 Mb Synthesizes the Vast Literature on One of the Hottest Areas in Biomedical Research Building a bridge between pharmacogenomics and statistics, Statistical and Computational Pharmacogenomics allows researchers to readily familiarize themselves with this promising and revolutionary area of science. It outlines the powerful statistical techniques used in the fast-growing field of pharmacogenomics, which seeks to understand the relationships between interpatient variability in drug response and specific genomic sites. Providing geneticists with the tools needed to understand and model the genetic variations for drug responses, this seminal work also equips statisticians with the motivation and ideas needed to explore genomic data. Exciting Implications for the Future of Drug Therapies In addition to providing a synthesis of statistical methodology for the pharmocogenomic study of drug response, this cutting-edge, authoritative text developseach method step-by-step, while keeping theoretical details to a minimum. It also presents detailed, worked examples that outline how to apply the discussed methods and outlines the necessary statistical and computational theories for genetic mapping of dynamic traits. Indicative of the depth of this groundbreaking, multidisciplinary research and its exciting implications for the future of drug therapies, it is now possible to document, map, and understand the structure and patterns of the human genome linked to drug response. The pioneering process of functional mapping has the potential to revolutionize the use of many medications with tailored treatment plans based on patients’ individual genetic makeup. This will ideally lead to optimal prescriptions, optimal administration times, and optimal dosage scheduling.

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